Product Description
Potential Uses
How PolyHeme® Is Made
Clinical Trial Experience
Non-Randomized
Trauma Trial
PolyHeme® Pivotal
Phase III Trial
Potential Battlefield Use
Development History
Selected Bibliography

 

Selected Bibliography

Dunne JR, Riddle MS, Danko J, Hayden R, Petersen K.
Blood transfusion is associated with infection and increased resource utilization in combat casualties.
Am Surg. 2006 Jul;72(7):619-25; discussion 625-6.

Dutton RP, Lefering R, Lynn M. Related Articles, Links
Database predictors of transfusion and mortality.
J Trauma. 2006 Jun;60(6 Suppl):S70-7.

Beale E, Zhu J, Chan L, Shulman I, Harwood R, Demetriades D.
Blood transfusion in critically injured patients: a prospective study.
Injury. 2006 May;37(5):455-65. Epub 2006 Feb 14.

Blumberg N.
Deleterious clinical effects of transfusion immunomodulation: proven beyond a reasonable doubt.
Transfusion. 2005 Aug;45(2 Suppl):33S-39S; discussion 39S-40S. Review. No abstract available.

Thyes C, Spahn DR.
Current Status of Artificial O(2) Carriers.
Anesthesiol Clin North America. 2005 Jun;23(2):373-89.

Ciesla DJ, Moore EE, Johnson JL, Burch JM, Cothren CC, Sauaia A.
A 12-year prospective study of postinjury multiple organ failure: has anything changed?
Arch Surg. 2005 May;140(5):432-8; discussion 438-40.

Handrigan MT, Bentley TB, Oliver JD, Tabaku LS, Burge JR, Atkins JL.
Choice of fluid influences outcome in prolonged hypotensive resuscitation after hemorrhage in awake rats.
Shock. 2005 Apr;23(4):337-43.

Sheppard FR, Moore EE, Johnson JL, Cheng AM, McLaughlin N, Silliman CC. Transfusion-induced leukocyte IL-8 gene expression is avoided by the use of human polymerized hemoglobin.
J Trauma. 2004 Oct;57(4):720-4; discussion 724-5.

Cothren CC, Moore EE, Long JS, Haenel JB, Johnson JL, Ciesla DJ.
Large volume polymerized haemoglobin solution in a Jehovah's Witness following abruptio placentae.
Transfus Med. 2004 Jun;14(3):241-6

Ciesla DJ, Moore EE, Johnson JL, Sauaia A, Cothren CC, Moore JB, Burch JM.
Multiple organ dysfunction during resuscitation is not postinjury multiple organ failure.
Arch Surg. 2004 Jun;139(6):590-4; discussion 594-5.

Moore FA, McKinley BA, Moore EE.
The next generation in shock resuscitation.
Lancet. 2004 Jun 12;363(9425):1988-96. Review.

Silliman CC, Moore EE, Johnson JL, Gonzalez RJ, Biffl WL.
Transfusion of the injured patient: proceed with caution.
Shock. 2004 Apr;21(4):291-9.

Shapiro NI, Kociszewski C, Harrison T, Chang Y, Wedel SK, Thomas SH. Related Isolated prehospital hypotension after traumatic injuries: a predictor of mortality?
J Emerg Med. 2003 Aug;25(2):175-9.

Norris EJ, Ness PM, Williams GM.
Use of a human polymerized hemoglobin solution as an adjunct to acute normovolemic hemodilution during complex abdominal aortic reconstruction.
J Clin Anesth. 2003 May;15(3):220-3.

Johnson JL, Moore EE, Gonzalez RJ, Fedel N, Partrick DA, Silliman CC.
Alteration of the postinjury hyperinflammatory response by means of resuscitation with a red cell substitute.
J Trauma. 2003 Jan;54(1):133-9; discussion 139-40.

Moore EE.
Blood substitutes: the future is now.
J Am Coll Surg. 2003 Jan;196(1):1-17.

Lanzkron S, Moliterno AR, Norris EJ, Gould SA, Segal J, Nuermberger EL, Ness PM.
Polymerized human Hb use in acute chest syndrome: a case report.
Transfusion. 2002 Nov;42(11):1422-7.

Gould SA, Moore EE, Hoyt DB, Ness PM, Norris EJ, Carson JL, Hides GA, Freeman IH, DeWoskin R, Moss GS.
The life-sustaining capacity of human polymerized hemoglobin when red cells might be unavailable.
J Am Coll Surg. 2002 Oct;195(4):445-52; discussion 452-5.

Raff JP, Dobson CE, Tsai HM.
Transfusion of polymerised human haemoglobin in a patient with severe sickle-cell anaemia.
Lancet. 2002 Aug 10;360(9331):464-5.

Carson JL, Noveck H, Berlin JA, Gould SA.
Mortality and morbidity in patients with very low postoperative Hb levels who decline blood transfusion.
Transfusion.
2002 Jul;42(7):812-8.

Cothren C, Moore EE, Offner PJ, Haenel JB, Johnson JL.
Blood substitute and erythropoietin therapy in a severely injured Jehovah's witness.
N Engl J Med. 2002 Apr 4;346(14):1097-8.

Johnson JL, Moore EE, Offner PJ, Partrick DA, Tamura DY, Zallen G, Silliman CC.
Resuscitation with a blood substitute abrogates pathologic postinjury neutrophil cytotoxic function.
J Trauma. 2001 Mar;50(3):449-55; discussion 456.

Chance JJ, Norris EJ, Kroll MH.
Mechanism of interference of a polymerized hemoglobin blood substitute in an alkaline phosphatase method.
Clin Chem. 2000 Sep;46(9):1331-7

LaMuraglia GM, O'Hara PJ, Baker WH, Naslund TC, Norris EJ, Li J, Vandermeersch E.
The reduction of the allogenic transfusion requirement in aortic surgery with a hemoglobin-based solution.
J Vasc Surg. 2000 Feb;31(2):299-308.

Johnson JL, Moore EE, Offner PJ, Haenel JB, Hides GA, Tamura DY.
Resuscitation of the injured patient with polymerized stroma-free hemoglobin does not produce systemic or pulmonary hypertension.
Am J Surg. 1998 Dec;176(6):612-7.

Heckbert SR, Vedder NB, Hoffman W, Winn RK, Hudson LD, Jurkovich GJ, Copass MK, Harlan JM, Rice CL, Maier RV.
Outcome after hemorrhagic shock in trauma patients.
J Trauma. 1998 Sep;45(3):545-9.

Gould SA, Moore EE, Hoyt DB, Burch JM, Haenel JB, Garcia J, DeWoskin R, Moss GS.
The first randomized trial of human polymerized hemoglobin as a blood substitute in acute trauma and emergent surgery.
J Am Coll Surg. 1998 Aug;187(2):113-20; discussion 120-2.

Sauaia A, Moore FA, Moore EE, Norris JM, Lezotte DC, Hamman RF.
Multiple organ failure can be predicted as early as 12 hours after injury.
J Trauma. 1998 Aug;45(2):291-301; discussion 301-3.

Gould SA, Moore EE, Hoyt DB, Burch JM, Haenel JB, Garcia J, DeWoskin R, Moss GS.
The first randomized trial of human polymerized hemoglobin as a blood substitute in acute trauma and emergent surgery.
J Am Coll Surg. 1998 Aug;187(2):113-20; discussion 120-2.

Gould SA, Moore EE, Moore FA, Haenel JB, Burch JM, Sehgal H, Sehgal L, DeWoskin R, Moss GS.
Clinical utility of human polymerized hemoglobin as a blood substitute after acute trauma and urgent surgery.
J Trauma. 1997 Aug;43(2):325-31; discussion 331-2.

Moore FA, Moore EE, Sauaia A.
Blood transfusion. An independent risk factor for postinjury multiple organ failure.
Arch Surg. 1997 Jun;132(6):620-4; discussion 624-5.

Houbiers JG, van de Velde CJ, van de Watering LM, Hermans J, Schreuder S, Bijnen AB, Pahlplatz P, Schattenkerk ME, Wobbes T, de Vries JE, Klementschitsch P, van de Maas AH, Brand A.
Transfusion of red cells is associated with increased incidence of bacterial infection after colorectal surgery: a prospective study.
Transfusion. 1997 Feb;37(2):126-34.

Gould SA, Moss GS.
Clinical development of human polymerized hemoglobin as a blood substitute.
World J Surg. 1996 Nov-Dec;20(9):1200-7. Review

Gould SA, Sehgal LR, Sehgal HL, Moss GS.
The development of hemoglobin solutions as red cell substitutes: hemoglobin solutions.
Transfus Sci. 1995 Mar;16(1):5-17. Review.

Gould SA, Sehgal LR, Rosen AL, Sehgal HL, Moss GS.
The efficacy of polymerized pyridoxylated hemoglobin solution as an O2 carrier.
Ann Surg. 1990 Apr;211(4):394-8.

Gould SA, Sehgal LR, Rosen AL, Sehgal HL, Moss GS. Related Articles, Links
The development of polymerized pyridoxylated hemoglobin solution as a red cell substitute.
Ann Emerg Med. 1986 Dec;15(12):1416-9.

Gould SA, Rosen AL, Sehgal LR, Sehgal HL, Moss GS. Related Articles, Links
Polymerized pyridoxylated hemoglobin: efficacy as an O2 carrier.
J Trauma. 1986 Oct;26(10):903-8.

Sehgal LR, Gould SA, Rosen AL, Sehgal HL, Moss GS.
Polymerized pyridoxylated hemoglobin: a red cell substitute with normal oxygen capacity.
Surgery. 1984 Apr;95(4):433-8.

Moss GS, Gould SA, Sehgal LR, Sehgal HL, Rosen AL.
Hemoglobin solution-from tetramer to polymer.
Surgery. 1984 Mar;95(3):249-55.

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