Non-Randomized
Trauma Trial in Hospital Setting
Results of this trial were presented in part
at the Clinical Congress of the American College of Surgeons, Chicago,
IL, in October 2001, and were subsequently published in the October
2002 issue of the Journal of the American College of Surgery.
In this study, 171 patients in the hospital setting
received rapid infusion of 1 to 20 units (1,000 g, 10 L) of PolyHeme®
in lieu of red cells as initial oxygen-carrying replacement in
trauma and urgent surgery. Some of these patients were kept alive
while losing virtually all of their blood during ongoing bleeding
and receiving only PolyHeme® as replacement. Observations in
these patients have suggested the life-sustaining potential of
PolyHeme® in the treatment of urgent life-threatening
blood loss and life-threatening hemoglobin levels.
Gould
S, Moore EE, Hoyt DB, et al., The Life-Sustaining Capacity of Human
Polymerized Hemoglobin when Red Cells Might Be Unavailable. J
Am College Surg 2002;195:445-455.
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